安徽医科大学生命科学学院许璇老师2025年接受硕士调剂(生物信息学方向)(1-2 名) 导师简介: 许璇,女,硕士研究生导师,安徽医科大学生命科学学院校聘副教授,主要研究方向为生物医学多组学数据的解析和病理机制的挖掘,疾病精准医疗模型的构建。特别聚焦于神经退行性疾病(如:阿尔茨海默症)的机制解析相关研究,通过生物信息学分析方法寻找新的个性化治疗策略及潜在药物靶点。 实验室网站: https://life.ahmu.edu.cn/teacher ... ff5514fd169c23.html 代表性成果: (1)论文 1. Xu X, Wang H, Bennett DA, Zhang QY, Meng XY, Zhang HY*. Characterization of brain resilience in Alzheimer's disease using polygenic risk scores and further improvement by integrating mitochondria-associated loci. J. Adv. Res. 2024;56:113-124. 2. Fei Wang; Jiaqi Wang; Tong Chen; Shuaibin Wang; XiangYu Meng; Yin Shen*; Xuan Xu*; Systematic Identification of Mitochondrial Signatures in Alzheimer’s Disease and Inflammatory Bowel Disease, Mol. Neurobiol. 2025 3. Xu X*, Wang JQ, Chen T, Wang SB, Wang F, He JW, Meng X-Y, Shen Y*. Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastoma. Front. Aging Neurosci. 2025, 17. 4. Xu X, Wang H, Zhang QY, Xiang-Yu M, XinXing L, Zhang HY*. Dissecting mitochondrial mechanism of Alzheimer’s Disease using gene dependency network and implications for prevention strategies. J Alzheimers Dis. 2023;95(4):1709-1722. 5. Xu X, Wang H, Bennett DA, Zhang QY, Wang G, Zhang HY*. Systems Genetic Identification of Mitochondrion-Associated Alzheimer's Disease Genes and Implications for Disease Risk Prediction. Biomedicines. 2022 Jul 24;10(8):1782. 6. Xu X#, Zhang QY#*, Chu XY, Quan Y, Lv BM, Zhang HY*. Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge. Viruses. 2021 Oct 20;13(11):2117. 7. Xu X, Zhang HY*. The Immunogenetics of Psoriasis and Implications for Drug Repositioning. Int J Mol Sci. 2017 Dec 8;18(12):2650. 8. Ye C-Q, Leng J, Jin M-Y, Meng Y-D, Zhao Z-Y, Meng F-X, Xu X, Fan S-S, Luo H-B, Meng X-Y. SysNatMed: rational natural medicine discovery by systems genetics[J]. Front. Pharmacol. 2025, 16. 9. Li X, Huang W, Xu X, Zhang HY, Shi Q*. Deciphering tissue heterogeneity from spatially resolved transcriptomics by the autoencoder-assisted graph convolutional neural network. Front Genet. 2023 May 25;14:1202409. 10. Wu N*, Xu X, Wang B, Li XM, Cheng YY, Li M, Xia XQ, Zhang YA. Anti-foodborne enteritis effect of galantamine potentially via acetylcholine anti-inflammatory pathway in fish. Fish Shellfish Immunol. 2020 Feb;97:204-215. 11. Wang H, Wang G, Zhu LD, Xu X, Diao B, and Zhang HY*. Subnetwork identification and chemical modulation for neural regeneration: A study combining network guided forest and heat diffusion model. Quantitative Biology 2018, 6: 321-333. 12. Wu N, Wang B, Cui Z-W, Zhang X-Y, Cheng Y-Y, Xu X, Li X-M, Wang Z-X, Chen D-D, Zhang Y-A. Integrative transcriptomic and microRNAomic profiling reveals immune mechanism for the resilience to soybean meal stress in fish gut and liver[J]. Front. Physiol. 2018, 9. 13. 陈魏红,麦可,许璇,刘子玄,张红雨,彭辉. 一种胶质细胞偶联人工神经网络模型. 小型微型计算机系统. 2022. 招生要求 1. 生物信息学相关专业,专业07开头 2. 积极进取,善于思考,富有自驱力,性格开朗,乐于团队合作 3. 具备 生物信息学或计算机背景,掌握 R/Python/Shell 编程者优先 4. 通过CET-6,需具备良好的英文文献阅读能力 研究与培养优势 • 优质科研环境:安医大生命科学学院提供一流的科研条件 • 前沿研究课题:涉及 多组学数据挖掘、精准医疗、神经退行性疾病机制解析 • 交叉学科培养:涵盖 生物信息学、计算机科学、医学 等多领域知识 欢迎热爱科研、志在探索生命科学奥秘的优秀学子加入! 联系方式:xuxuan123025@163.com (邮件标题:硕士调剂+姓名+专业+分数) |
北大博士后团队开发和维护,最权威、最实时、覆盖最广的调剂信息。